|
Enteritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results showed that, compared with the control group, dietary CT (1) induced intestinal histopathological lesions and aggravated enteritis; (2) decreased the lysozyme and acid phosphatase activities, complement 3 (C3), C4 and immunoglobulin M contents, and down-regulated the Hepcidin, liver-expressed antimicrobial peptide(LEAP)-2A, LEAP-2B, Mucin2 and β-defensin-1 mRNA levels in the proximal intestine (PI), mid intestine (MI) and distal intestine (DI) (P < 0·05); (3) down-regulated the mRNA levels of anti-inflammatory cytokines transforming growth factor (TGF)-β1, TGF-β2 (not in MI and DI), IL-4/13A (not IL-4/13B), IL-10 and IL-11 partly correlated with target of rapamycin (TOR) signalling; (4) up-regulated the mRNA levels of pro-inflammatory cytokines interferon-γ2 (IFN-γ2), interleukin-1β (IL-1β), IL-6, IL-8 (not in PI), IL-12p35, IL-12p40, IL-15 and IL-17D partly related to nuclear factor kappa B (NF-κB) signalling in the intestine of on-growing grass carp.
|
31831090 |
2020 |
|
Tuberculosis, Pulmonary
|
0.060 |
Biomarker
|
disease |
BEFREE |
The risk of pulmonary tuberculosis was positively associated with the concentrations of interleukin-27 and adenosine deaminase in bronchoalveolar lavage fluids.
|
31819557 |
2019 |
|
Malignant neoplasm of lung
|
0.050 |
Biomarker
|
disease |
BEFREE |
Interleukin-27 levels in bronchoalveolar lavage fluids could be used for diagnostic purpose for pulmonary tuberculosis, with the cutoff value of 7.867 pg/mL; interleukin-27 had a sensitivity of 68.8% and specificity of 100% for the differential diagnosis of pulmonary tuberculosis (sputum-negative and sputum-positive PTB) from lung cancer.
|
31819557 |
2019 |
|
Carcinoma of lung
|
0.050 |
Biomarker
|
disease |
BEFREE |
Interleukin-27 levels in bronchoalveolar lavage fluids could be used for diagnostic purpose for pulmonary tuberculosis, with the cutoff value of 7.867 pg/mL; interleukin-27 had a sensitivity of 68.8% and specificity of 100% for the differential diagnosis of pulmonary tuberculosis (sputum-negative and sputum-positive PTB) from lung cancer.
|
31819557 |
2019 |
|
Primary malignant neoplasm of lung
|
0.050 |
Biomarker
|
disease |
BEFREE |
Interleukin-27 levels in bronchoalveolar lavage fluids could be used for diagnostic purpose for pulmonary tuberculosis, with the cutoff value of 7.867 pg/mL; interleukin-27 had a sensitivity of 68.8% and specificity of 100% for the differential diagnosis of pulmonary tuberculosis (sputum-negative and sputum-positive PTB) from lung cancer.
|
31819557 |
2019 |
|
Septicaemia due to gram-negative organism, unspecified
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In the present work, we hypothesized that increased levels of IL-27 predispose neonatal mice to more severe infection during Gram-negative sepsis.
|
31818960 |
2020 |
|
Sepsis of the newborn
|
0.010 |
Biomarker
|
disease |
BEFREE |
In contrast, our findings demonstrate that IL-27 indirectly promotes an inflammatory cytokine response during neonatal sepsis by directly compromising control of bacteria that drive the inflammatory response.
|
31818960 |
2020 |
|
Bacterial sepsis of newborn
|
0.010 |
Biomarker
|
disease |
BEFREE |
In contrast, our findings demonstrate that IL-27 indirectly promotes an inflammatory cytokine response during neonatal sepsis by directly compromising control of bacteria that drive the inflammatory response.
|
31818960 |
2020 |
|
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Our study reveals that IL-27 contributes to autoimmunity in NOD mice through multiple mechanisms and provides substantial evidence to support its pathogenic role in human T1D.
|
31801074 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our study reveals that IL-27 contributes to autoimmunity in NOD mice through multiple mechanisms and provides substantial evidence to support its pathogenic role in human T1D.
|
31801074 |
2019 |
|
Septicemia
|
0.060 |
Biomarker
|
disease |
BEFREE |
IL-27 was elevated in sepsis patients with acute hepatic injury, which correlated with the Acute Physiologic Assessment and Chronic Health Evaluation II (APACHEII) scores, Sequential Organ Failure Assessment (SOFA) scores, and procalcitonin, C-reactive protein, IL-6, and TNF-α expression.
|
31786500 |
2020 |
|
Sepsis
|
0.060 |
Biomarker
|
disease |
BEFREE |
IL-27 was elevated in sepsis patients with acute hepatic injury, which correlated with the Acute Physiologic Assessment and Chronic Health Evaluation II (APACHEII) scores, Sequential Organ Failure Assessment (SOFA) scores, and procalcitonin, C-reactive protein, IL-6, and TNF-α expression.
|
31786500 |
2020 |
|
Sjogren's Syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
<b>Methods</b>: The SS-like symptoms were evaluated in IL-27 deficient and recombinant IL-27-treated NOD mice.
|
31754394 |
2019 |
|
Renal Cell Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Thirty-four cultured human tumor lines [18 melanomas (MEL), 12 renal cell carcinomas (RCC), 3 squamous cell carcinomas of the head and neck (SCCHN), and 1 non-small-cell lung carcinoma (NSCLC)] and peripheral blood monocytes (Monos) were treated with cytokines that we detected in the PD-L1+ TME by gene expression profiling, including IFN-g, IL-1a, IL-10, IL-27 and IL-32g.
|
31730010 |
2019 |
|
Kidney Failure, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
We used a mouse model of renal ischemia/reperfusion (I/R) injury to investigate whether IL-27 has a therapeutic potential for the treatment of AKI.
|
31722339 |
2019 |
|
Ischemia of kidney
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interleukin-27 Ameliorates Renal Ischemia-Reperfusion Injury through Signal Transducers and Activators of Transcription 3 Signaling Pathway.
|
31722339 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Because there is a particular link of IL-23/Th17 axis in the development of cancer and IL-27 has been considered a potential treatment for cancer, we evaluated the gastric and serum concentrations of IL-27 in two mutually exclusive Helicobacter pylori-associated diseases, gastric cancer (GC) and duodenal ulcer (DU).
|
31702083 |
2020 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Because there is a particular link of IL-23/Th17 axis in the development of cancer and IL-27 has been considered a potential treatment for cancer, we evaluated the gastric and serum concentrations of IL-27 in two mutually exclusive Helicobacter pylori-associated diseases, gastric cancer (GC) and duodenal ulcer (DU).
|
31702083 |
2020 |
|
Duodenal Ulcer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Gastric IL-27 concentrations were positively correlated with increased degree of mononuclear and polymorphonuclear cells on the antral gastric mucosa of DU patients in consonance with the DU gastritis pattern.
|
31702083 |
2020 |
|
Gastritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
IL-27 was also detected in the gastritis patients and in the H pylori-positive blood donors.
|
31702083 |
2020 |
|
Gonorrhea
|
0.010 |
Biomarker
|
disease |
BEFREE |
IL-27 was not detected in GC patients, but the cytokine concentration was very high in the patients with DU.
|
31702083 |
2020 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
Because there is a particular link of IL-23/Th17 axis in the development of cancer and IL-27 has been considered a potential treatment for cancer, we evaluated the gastric and serum concentrations of IL-27 in two mutually exclusive Helicobacter pylori-associated diseases, gastric cancer (GC) and duodenal ulcer (DU).
|
31702083 |
2020 |
|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
0.010 |
Biomarker
|
disease |
BEFREE |
Because there is a particular link of IL-23/Th17 axis in the development of cancer and IL-27 has been considered a potential treatment for cancer, we evaluated the gastric and serum concentrations of IL-27 in two mutually exclusive Helicobacter pylori-associated diseases, gastric cancer (GC) and duodenal ulcer (DU).
|
31702083 |
2020 |
|
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Because there is a particular link of IL-23/Th17 axis in the development of cancer and IL-27 has been considered a potential treatment for cancer, we evaluated the gastric and serum concentrations of IL-27 in two mutually exclusive Helicobacter pylori-associated diseases, gastric cancer (GC) and duodenal ulcer (DU).
|
31702083 |
2020 |
|
Aortic Aneurysm, Abdominal
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we report a pathogenic role for the interleukin-27 receptor (IL-27R) in AAA, as genetic ablation of IL-27R protects mice from the disease development.
|
31695038 |
2019 |